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KMID : 1161420210240050527
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Journal of Medicinal Food
2021 Volume.24 No. 5 p.527 ~ p.532
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Administration of Herbarium Mixture (Guazuma ulmifolia/Tecoma stans) on Metabolic Profile in Type 2 Diabetes Mellitus Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
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Pascoe-Gonzalez Sara
Ramos-Zavala Maria Guadalupe
Ahued Miguel Angel Buenrostro
Hernandez-Gonzalez Sandra Ofelia
Cardona-Munoz Ernesto German
Garcia-Benavides Leonel
Grover-Paez Fernando
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Abstract
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The use of herbarium mixture has been empirical, and the properties are not yet known. The aim of this study was to evaluate the effect of oral administration of herbarium mixture (Guazuma ulmifolia [G. ulmifolia]/Tecoma stans [T. stans]) on metabolic profile in patients with type 2 diabetes mellitus (T2DM). A randomized, double-blind, placebo-controlled, clinical trial was carried out in 40 patients with T2DM. They were between 40 and 65 years of age, with body mass index (BMI) between 25.0 and 34.9?kg/m2 and HbA1c >7.0%. BMI, waist circumference, fasting glucose, HbA1c, lipids, kidney, and liver function were measured. The patients were randomly assigned to receive the herbarium mixture (G. ulmifolia/T. stans) 400?mg before each meal, or placebo for 90 days. Herbarium mixture group showed decreased waist circumference (99?±?14 vs. 98?±?15?cm; P?=?.019), fasting glucose (12.0?±?5.7 vs. 10.3?±?5.1?mM; P?=?.019), and HbA1c (9.9%?±?2.7% vs. 8.9%?±?2.5%, P?=?.002). In conclusion, the administration of herbarium mixture (G. ulmifolia/T. stans) improved the glycemic profile in patients with T2DM. ClinicalTrial registration: NCT03313856 ClinicalTrials.gov
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KEYWORD
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glucose, G. ulmifolia, HbA1c, T. stans, type 2 diabetes
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